This 15-night Royal Caribbean itinerary links San Diego to Tampa, threading 8 ports of call through 7 countries with 8 days at sea to unwind aboard Royal Caribbean Serenade of the Seas.
Why sail this route
You unpack once and let the ship do the travelling: 7 countries over 15 nights, starting in San Diego and finishing in Tampa, with a new port waiting most mornings instead of airports and hotel check-ins.
The pacing runs to 8 port days and 8 days at sea — time to enjoy the ship between stops.
Good to know
- Best for
- Repositioning & bucket-list cruisers
- Season
- Autumn sailing
- Route
- San Diego → Tampa
- Pace
- 8 port days · 8 sea days
Day-by-Day Itinerary
Hover a day to find it on the map.
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Day1
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Day2At SeaA Day at Sea
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Day3At SeaA Day at Sea
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Day4
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Day5At SeaA Day at Sea
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Day6At SeaA Day at Sea
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Day7
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Day8At SeaA Day at Sea
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Day9
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Day10At SeaA Day at Sea
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Day11Panama Canal (Cruising Canal) 6:00 AM – 6:00 PMExplore Panama Canal
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Day12
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Day13At SeaA Day at Sea
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Day14
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Day15At SeaA Day at Sea
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Day16
The Ship
Your home for all 15 nights aboard Royal Caribbean Serenade of the Seas — so you unpack once and wake up somewhere new each morning.
About This Cruise
The 15 Night Panama Canal Eastward Cruise is a 15-night one-way itinerary aboard Royal Caribbean Serenade of the Seas. You board in San Diego and disembark in Tampa, calling at 8 ports across 7 countries along the way.
In sequence the voyage takes in California (San Diego), Mexico (Puerto Vallarta), Guatemala (Puerto Quetzal), Costa Rica (Puntarenas), Colombia (Cartagena), Grand Cayman (George Town) and 1 more.
As a one-way sailing you'll fly into San Diego and home from Tampa, so it's worth checking the two gateways before you book. Longer hops are crossed on the 8 days at sea, keeping daylight hours for the ports. Sailing dates, cabin availability and fares vary by season — use Check Dates & Prices for live pricing, or call our team to talk through the options.