This 22-night Regent Seven Seas itinerary loops out and back from Panama City, threading 9 ports of call through 6 countries with 12 days at sea to unwind aboard Regent Seven Seas Grandeur.
Why sail this route
You unpack once and let the ship do the travelling: 6 countries over 22 nights, beginning and ending in Panama City, with a new port waiting most mornings instead of airports and hotel check-ins.
The pacing runs to 9 port days and 12 days at sea — time to enjoy the ship between stops.
Good to know
- Best for
- Grand-voyage & long-cruise travellers
- Season
- Spring sailing
- Fly into
- Panama City — round-trip
- Pace
- 9 port days · 12 sea days
Day-by-Day Itinerary
Hover a day to find it on the map.
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Day1
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Day2Panama Canal (Cruising Canal)Explore Panama Canal
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Day3At SeaA Day at Sea
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Day4
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Day5At SeaA Day at Sea
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Day6
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Day7At SeaA Day at Sea
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Day8At SeaA Day at Sea
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Day9At SeaA Day at Sea
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Day10At SeaA Day at Sea
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Day11
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Day12At SeaA Day at Sea
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Day13
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Day14
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Day15At SeaA Day at Sea
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Day16At SeaA Day at Sea
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Day17At SeaA Day at Sea
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Day18
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Day19At SeaA Day at Sea
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Day20
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Day21At SeaA Day at Sea
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Day22Panama Canal (Cruising Canal)Explore Panama Canal
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Day23
The Ship
Your home for all 22 nights aboard Regent Seven Seas Grandeur — so you unpack once and wake up somewhere new each morning.
About This Cruise
The 22 Night Journey To The Amazon Panama City To Panama City is a 22-night round-trip itinerary aboard Regent Seven Seas Grandeur. You board and return in Panama City, calling at 9 ports across 6 countries along the way.
In sequence the voyage takes in Panama (Panama City), Aruba (Oranjestad), Trinidad and Tobago (Trinidad), Brazil (Manaus, Boca da Valeria, Santarem), Grenada (St Georges), Curacao (Willemstad) and 1 more.
Because it's round-trip from Panama City, you fly into and out of a single city and unpack just once. Longer hops are crossed on the 12 days at sea, keeping daylight hours for the ports. Sailing dates, cabin availability and fares vary by season — use Check Dates & Prices for live pricing, or call our team to talk through the options.