This 22-night MSC itinerary links Palermo to Santos (Sao Paulo), threading 12 ports of call through 6 countries with 11 days at sea to unwind aboard MSC Virtuosa.
Why sail this route
You unpack once and let the ship do the travelling: 6 countries over 22 nights, starting in Palermo and finishing in Santos (Sao Paulo), with a new port waiting most mornings instead of airports and hotel check-ins.
The pacing runs to 12 port days and 11 days at sea — time to enjoy the ship between stops.
Good to know
- Best for
- Grand-voyage & long-cruise travellers
- Season
- Autumn sailing
- Route
- Palermo → Santos (Sao Paulo)
- Pace
- 12 port days · 11 sea days
Day-by-Day Itinerary
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The Ship
Your home for all 22 nights aboard MSC Virtuosa — so you unpack once and wake up somewhere new each morning.
About This Cruise
The 22 Night MSC Grand Voyages is a 22-night one-way itinerary aboard MSC Virtuosa. You board in Palermo and disembark in Santos (Sao Paulo), calling at 12 ports across 6 countries along the way.
In sequence the voyage takes in Sicily (Palermo), Italy (Naples, Livorno), France (Marseille), Spain (Barcelona, Malaga), Canary Islands (Tenerife) and Brazil (Maceio, Salvador De Bahia, Rio De Janeiro and 2 more).
As a one-way sailing you'll fly into Palermo and home from Santos (Sao Paulo), so it's worth checking the two gateways before you book. Longer hops are crossed on the 11 days at sea, keeping daylight hours for the ports. Sailing dates, cabin availability and fares vary by season — use Check Dates & Prices for live pricing, or call our team to talk through the options.